Skyscanner home

4-star hotels in Cayo Guillermo

Find the best 4-star hotel in Cayo Guillermo for your dates, by price or preference

Compare 4-star hotel deals across hundreds of providers, all in one place

Look out for 4-star hotels in Cayo Guillermo with free cancellation or excellent ratings

Trusted Cayo Guillermo hotel providers

See all hotels in Cayo Guillermo

Prices may change – pop in your dates for the best estimate. Note that prices are based on previous traveller searches and partner prices.
Prices may change – pop in your dates for the best estimate. Note that prices are based on previous traveller searches and partner prices.
View more hotels

4-star hotels in Cayo Guillermo: FAQs

You can always cancel or amend your hotel reservation if you need to, but look out for hotels in Cayo Guillermo with free cancellation or flexible booking options if you want to protect your money. Some hotels allow you to cancel and get your money back if your plans change.
The cheapest month to stay in a hotel in Cayo Guillermo is August, with an average price of R 1,624 per night. The most expensive month is January, when the average room rate can rise to R 2,839 per night. These average prices are based on all the hotels we found – from hostels through to fancy 5-star hotels.

Plan your trip to Cayo Guillermo