Cheap Flights from San Diego International to Knoxville

Compare San Diego International to Knoxville flight deals

Find the cheapest month or even day of the year to fly to Knoxville

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Flight deals from San Diego International to Knoxville

Looking for a cheap last-minute deal or the best return flight from San Diego International to Knoxville? Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from San Diego International to Knoxville

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like San Diego International to Knoxville flights are currently cheapest in September.

San Diego International to Knoxville: Alternative routes

Compare routes from San Diego International to Knoxville below. You may find an airport to fly into that's cheaper, faster, or easier than Knoxville.

San Diego to Knoxville: Flight information

The things to know before you go.
Cheapest flight foundR 2,257
Cheapest month to flySeptember

Finding cheap flights from San Diego International to Knoxville: Frequently asked questions

The best price we found for a return flight from San Diego International to Knoxville is R 4,102. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from San Diego International to Knoxville. But we found flights with one or more stops from R 4,102.
As of July 2025, there are no flights flying from San Diego International to Knoxville.
The cheapest month to fly from San Diego International to Knoxville is usually August.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from San Diego International Airport to Knoxville Airport on Saturday, 16 August 2025.
No airlines currently offer direct flights between San Diego International Airport and Knoxville Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Knoxville but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Knoxville is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Frontier Airlines offers the cheapest flight tickets to Knoxville.

Travelling from San Diego International Airport (SAN) to McGhee Tyson Airport (TYS): what you need to know

  • For a smooth journey, turn up at the airport two hours ahead of international flights and one hour before domestic departures. This will give you enough time to catch your SAN to TYS flight.

  • Be prepared for bigger queues during popular months like July. Arriving up to four hours ahead of international flights and two hours for domestic departures will help ensure a smooth travel experience.

  • Think about adding a stopover when booking your ticket from San Diego International Airport to McGhee Tyson Airport. Simply uncheck 'Direct flights only' to break up your trip, or perhaps explore a new destination along the way. Here are some options between SAN and TYS:

    • William P. Hobby Airport

    • Austin-Bergstrom International Airport

    • Harry Reid Airport (formerly McCarran Airport)

How to find the cheapest flights from San Diego International Airport (SAN) to McGhee Tyson Airport (TYS)

  • R 2,257 is currently the lowest price for a one-way San Diego International Airport to McGhee Tyson Airport flight. A return flight starts at R 4,102. These prices can change depending on demand and availability.

  • To find cheap tickets from SAN to TYS, book early. Airlines generally offer lower prices when flights are first released.

  • If you can be flexible with your trip dates, use the 'Whole month' search function. It'll find the cheapest price across every month when searching for a flight from San Diego International Airport to McGhee Tyson Airport.

  • You don't need to check every day to find out if fares have gone down when you create a Price Alert. We'll send you an update as soon as there's a change in price on cheap flights from SAN to TYS.

  • Tailor your flights using filters. Pick your preferred arrival and departure times, total journey duration and airlines. You can also sort your results by 'Fastest,' 'Cheapest' or 'Best' flights from San Diego International Airport to McGhee Tyson Airport.

Handy information about San Diego International Airport (SAN)

  • SAN is located at Airport Drive.

  • 71.38% of flights taking off from San Diego International Airport reach their destination on time.

  • San Diego International Airport is around 5 kilometres from central San Diego. If you're catching a cab, ride-sharing or driving from the centre, it'll take 10 minutes or so to get there, depending on the traffic.

  • Planning to take public transport? Expect a journey time of around 20 minutes.

  • Catching an early flight from San Diego International Airport to McGhee Tyson Airport? Avoid the hassle of rushing to the airport (and sneak in some extra precious sleep) by choosing one of these hotels near SAN:

Arriving at McGhee Tyson Airport (TYS)

  • The last thing you need is a lengthy journey to your hotel if you're getting in late on a San Diego International Airport to McGhee Tyson Airport flight. Check in to one of these accommodation options near TYS instead:

  • Hit the road running by picking up a McGhee Tyson Airport rental car. Grab your wheels from Budget, Alamo or Avis to explore Knoxville and beyond.

  • For the lowest price, reserve your ride from McGhee Tyson Airport about three weeks before you travel.

Getting from McGhee Tyson Airport (TYS) to central Knoxville

  • The address for TYS is 2055 Alcoa Highway.

  • McGhee Tyson Airport is roughly 23 kilometres from central Knoxville. The drive time takes around 20 minutes.

When to fly to McGhee Tyson Airport (TYS)

  • The quietest month for a flight from San Diego International Airport to McGhee Tyson Airport is February, while July is the busiest. Pick the best time to go to Knoxville based on whether you prefer a bustling atmosphere or a more laid-back vibe.

  • Book your flight from San Diego International Airport to McGhee Tyson Airport for July if you'd like to explore Knoxville during its warmest month. You can expect temperatures of between 17ºC (63ºF) and 32ºC (90ºF).

  • Look for cheap tickets from SAN to TYS in January if you like cooler conditions. Temperatures are at their lowest around then, ranging between -6ºC (21ºF) and 11ºC (52ºF) on average.

Explore more of United States

  • Columbus is just one of the many places in United States waiting to be explored once you've taken in the sights of Knoxville. Around 451 kilometres away to the north, its best attractions include Franklin Park Conservatory and Botanical Gardens, Ohio Statehouse and German Village.

  • If there's time to check out another major stop in United States, head for Indianapolis, roughly 467 kilometres north-west of Knoxville. The Children's Museum of Indianapolis, Indianapolis Museum of Art and Indianapolis Zoo are key highlights.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.