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Cheap Flights from Santo Domingo to Panama City

Compare Santo Domingo to Panama City flight deals

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Flight deals from Santo Domingo to Panama City

Looking for a cheap last-minute deal or the best return flight from Santo Domingo to Panama City? If you want to travel next month, return fares start from R 8,586. Find the lowest prices on one-way and return tickets right here.
Panama City.R 3,937 per passenger.Departing Tue, 21 Apr.One-way flight with Wingo.Outbound indirect flight with Wingo, departs from Santo Domingo Las Americas on Tue, 21 Apr, arriving in Balboa.Price includes taxes and charges.From R 3,937, select.
Panama City.R 3,947 per passenger.Departing Sat, 1 Aug.One-way flight with Wingo.Outbound indirect flight with Wingo, departs from Santo Domingo Las Americas on Sat, 1 Aug, arriving in Balboa.Price includes taxes and charges.From R 3,947, select.
Panama City.R 3,990 per passenger.Departing Tue, 5 May.One-way flight with Wingo.Outbound indirect flight with Wingo, departs from Santo Domingo Las Americas on Tue, 5 May, arriving in Balboa.Price includes taxes and charges.From R 3,990, select.
Panama City.R 4,066 per passenger.Departing Thu, 4 Jun.One-way flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Thu, 4 Jun, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 4,066, select.
Panama City.R 4,120 per passenger.Departing Tue, 3 Nov.One-way flight with Wingo.Outbound indirect flight with Wingo, departs from Santo Domingo Las Americas on Tue, 3 Nov, arriving in Balboa.Price includes taxes and charges.From R 4,120, select.
Panama City.R 4,153 per passenger.Departing Fri, 11 Sep.One-way flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 11 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 4,153, select.
Panama City.R 4,279 per passenger.Departing Sat, 4 Jul.One-way flight with Wingo.Outbound indirect flight with Wingo, departs from Santo Domingo Las Americas on Sat, 4 Jul, arriving in Balboa.Price includes taxes and charges.From R 4,279, select.
Panama City.R 4,358 per passenger.Departing Fri, 12 Feb.One-way flight with Arajet.Outbound indirect flight with Arajet, departs from Santo Domingo Las Americas on Fri, 12 Feb, arriving in Balboa.Price includes taxes and charges.From R 4,358, select.
Panama City.R 4,431 per passenger.Departing Fri, 4 Dec.One-way flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 4 Dec, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 4,431, select.
Panama City.R 9,654 per passenger.Departing Mon, 20 Apr.One-way flight with Copa.Outbound direct flight with Copa departs from Santo Domingo Las Americas on Mon, 20 Apr, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 9,654, select.
Panama City.R 9,775 per passenger.Departing Fri, 1 May.One-way flight with Copa.Outbound direct flight with Copa departs from Santo Domingo Las Americas on Fri, 1 May, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 9,775, select.
Panama City.R 9,885 per passenger.Departing Thu, 4 Jun.One-way flight with Copa.Outbound direct flight with Copa departs from Santo Domingo Las Americas on Thu, 4 Jun, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 9,885, select.
Panama City.R 10,082 per passenger.Departing Sun, 7 Feb.One-way flight with Copa.Outbound direct flight with Copa departs from Santo Domingo Las Americas on Sun, 7 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 10,082, select.
Panama City.R 10,082 per passenger.Departing Thu, 23 Jul.One-way flight with Copa.Outbound direct flight with Copa departs from Santo Domingo Las Americas on Thu, 23 Jul, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 10,082, select.
Panama City.R 10,082 per passenger.Departing Sun, 27 Sep.One-way flight with Copa.Outbound direct flight with Copa departs from Santo Domingo Las Americas on Sun, 27 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 10,082, select.
Panama City.R 10,085 per passenger.Departing Thu, 10 Dec.One-way flight with Copa.Outbound direct flight with Copa departs from Santo Domingo Las Americas on Thu, 10 Dec, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 10,085, select.

Find the cheapest month to fly from Santo Domingo to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Santo Domingo to Panama City flights are currently cheapest in April.
Apr
from R 3,937
May
from R 3,990
Jun
from R 4,066
Jul
from R 4,279
Aug
from R 3,947
Sep
from R 4,153
Oct
Find prices
Nov
from R 4,120
Dec
from R 4,431
Jan
Find prices
Feb
from R 4,358
Mar
Find prices

Direct flights from Santo Domingo to Panama City

Alternative Santo Domingo to Panama City routes

Looking for the cheapest, fastest or easiest route from Santo Domingo to Panama City? You could fly into the following airports instead.

Panama City Paitilla

5km from central Panama City
Closest
from R 9,564
Search flights

Balboa

5km from central Panama City
Cheapest
from R 3,937
Search flights

Panama City Tocumen International

18km from central Panama City
from R 4,066
Search flights

Santo Domingo to Panama City: Flight information

The things to know before you go.
Cheapest flight foundR 3,937
Cheapest month to flyApril
Average flight time2 hrs, 36 mins
Most popular airlineCopa
Average flights per week340

Finding cheap flights from Santo Domingo to Panama City: Frequently asked questions

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
The best price we found for a return flight from Santo Domingo to Panama City is R 8,263. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
2 hours and 36 minutes is the average flight time from Santo Domingo to Panama City.
Copa, KLM and Air France fly direct from Santo Domingo to Panama City.
As of April 2026, there are 85 flights per week flying from Santo Domingo to Panama City.
The cheapest month to fly from Santo Domingo to Panama City is usually May.
If you're flying from Santo Domingo, the cheapest airport near Panama City is Balboa – which is 4.9 km away from the centre of Panama City. We've found flights into this airport from R 8,263.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Santo Domingo to Panama City on Tuesday, 5 May 2026.
Yes – the average flight time is 2 hours and 36 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.
In April, the average temperature is usually around 28°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
The cheapest airline that flies to Panama City is Wingo. And the cheapest airline that flies to Balboa Airport is Copa.

Flying from Santo Domingo to Panama City: what you need to know

  • Santo Domingo is home to two main airports where you can start your adventure. Explore your options for reserving a flight from Santo Domingo to Panama City departing from Las Americas International Airport (SDQ) or Dr. Joaquin Balaguer International Airport (JBQ).

  • Tocumen International Airport (PTY) and Panama Pacifico Airport (BLB) are Panama City's chief entry points.

  • The average time for a direct Santo Domingo to Panama City flight is 2 hours 35 minutes.

  • The timezone in Panama City is UTC-5, which is one hour behind Santo Domingo.

  • With 29 weekly flights between the two airports, Las Americas International Airport (SDQ) to Tocumen International Airport (PTY) is the busiest route. Board the first flight from Santo Domingo to Panama City with Copa Airlines at 05:14. If you'd like to make the most of your day before you fly, the last departure from SDQ to PTY is with Copa Airlines at 18:38.

  • For stress-free travel, arrive at the airport two hours ahead of international flights and one hour before domestic departures. This leaves you with plenty of time to catch your Santo Domingo to Panama City flight.

  • During popular months like August, you'll want to get to the airport earlier. Plan to arrive two hours before domestic departures and four hours ahead of international flights whenever you're flying during high season in general.

How to find the cheapest flights from Santo Domingo to Panama City

  • Lock in cheap Santo Domingo to Panama City flights by booking nine months ahead. According to our research, that's the sweet spot for landing a bargain.

  • December is the best month for landing an awesome deal on a plane ticket from Santo Domingo to Panama City. If you're looking to travel at a different time of year, the 'Whole month' tool will give you the lowest prices for each month.

  • Snapping up a cheap flight from Santo Domingo to Panama City is easy with Price Alerts. Simply set up one of these automatic alerts and we'll notify you as soon as a better deal is available.

  • Save money on your Santo Domingo to Panama City flight with the help of our filters. Select your ideal duration, number of stops and airlines, then sort the results by 'Cheapest' for the best deals.

Flying from Santo Domingo

Las Americas International Airport (SDQ)

  • Take off from Las Americas International Airport (SDQ) on a nonstop flight from Santo Domingo to Panama City. From SDQ, you can travel directly to Tocumen International Airport (PTY).

  • Lock in your Santo Domingo to Panama City plane tickets with Copa Airlines. This airline is a top pick for direct flights from SDQ.

  • We make it simple to find a Santo Domingo to Panama City flight with a stopover. To see all your options departing from Las Americas International Airport, deselect 'Direct flights only.' Then, choose a flight with a stop long enough to tour your chosen city. Top stopovers include:

    • El Dorado International Airport (BOG)

    • Jose Maria Cordova International Airport (MDE)

    • Juan Santamaria International Airport (SJO)

  • Central Santo Domingo to SDQ is around 27 kilometres. Depending on traffic conditions, it'll take about 30 minutes to get there if you're ride-sharing, catching a cab or driving.

  • Booked an early flight from Santo Domingo to Panama City? Avoid rushing to the airport (and sneak in some extra snooze time) by choosing one of these stays near Las Americas International Airport:

  • 72.45% of flights that depart Las Americas International Airport reach their destination on time.

Arriving in Panama City

Tocumen International Airport (PTY)

  • The distance from Tocumen International Airport (PTY) to central Panama City is approximately 16 kilometres. It'll take you around 20 minutes to reach the centre driving.

  • It usually takes 1 hour 5 minutes to get there on public transport.

  • If you have a late flight from Santo Domingo to Panama City, few things beat the convenience of staying close to the terminal. Grab your luggage from the carousel and then be showered and relaxing soon after at one of these hotels near PTY:

  • Follow your own route with a Tocumen International Airport rental car. Book your wheels from Avis, Dollar or MEX and discover more of Panama City and beyond.

  • To get the best deal, reserve your ride from Tocumen International Airport about three weeks in advance of your Santo Domingo to Panama City flight.

Marcos A. Gelabert International Airport (PAC)

  • Once your flight from Santo Domingo to Panama City has hit the runway, you can make your way to the city centre in about 5 minutes by car. Central Panama City is approximately 2 kilometres from Marcos A. Gelabert International Airport (PAC).

  • If you travel by public transport, you'll reach the centre in 25 minutes or so.

  • After your flight from Santo Domingo to Panama City, kick back at a hotel near BLB. These are some great options that'll help you switch to relaxation mode:

  • Thrifty, Avis and Alamo make picking up a Marcos A. Gelabert International Airport rental car simple. These trusted providers are located in or around the terminal and will have you behind the wheel before you know it.

  • Snap up the best price by securing your ride from PAC three weeks in advance. You can also expect to have a greater range of vehicles.

Panama Pacifico Airport (BLB)

  • Panama Pacifico Airport (BLB) is roughly 11 kilometres from the centre of Panama City. It'll take you about 20 minutes to reach the city centre in a ride-share or cab once you've stepped off your flight from Santo Domingo to Panama City.

  • Begin your travels without stressing over how to arrive at your destination with a Panama Pacifico Airport rental car. You can book a set of wheels from trusted companies here like Sixt, Dollar and Thrifty.

  • Plan ahead and pocket the savings. Book your vehicle from BLB one week before your flight from Santo Domingo to Panama City for the best rates.

Best time to go to Panama City

  • June is the busiest month for flights from Santo Domingo to Panama City. To skip the crowds, go to Panama City in February.

  • The warmest month in Panama City is March, with temperatures ranging between 21ºC (70ºF) and 32ºC (90ºF). Book your Santo Domingo to Panama City ticket then if that's your definition of good weather.

  • Look for cheap flights from Santo Domingo to Panama City in February if you'd rather travel when it's cooler. Temperatures are at their lowest then, ranging between 22ºC (72ºF) and 31ºC (88ºF) on average.

More about Panama City

  • After booking your flight from Santo Domingo to Panama City, find a hotel that keeps you close to what you want to see. Make one of these accommodation options your base for exploring Panama City:

  • All great journeys should include some sightseeing. Panama Canal Museum, Casco Viejo and Cinta Costera are must-do's during your Panama City adventure.

Explore more of Panama

  • You've seen Panama City, now it's time to discover other corners of Panama. Travel about 6 kilometres north to San Miguelito to tick off its leading attractions. From Iglesia Cristo Luz del Mundo to IDMJI SAN MIGUELITO and Iglesia Bautista Independiente Emanuel, you'll have a full itinerary ahead.

  • Around 11 kilometres north-east of Panama City, Juan Díaz is another favourite stop in Panama. No visit is complete without checking out Malecon Costa Del Este, El Patio Human Friendly and Parque Los Robles Sur.

Plan the rest of your trip from Santo Domingo to Panama City

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.