Cheap Flights from Santo Domingo to Panama City

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Flight deals from Santo Domingo to Panama City

Looking for a cheap last-minute deal or the best return flight from Santo Domingo to Panama City? If you want to travel next month, return fares start from R 7,245. Find the lowest prices on one-way and return tickets right here.

Panama City.R 3,480 per passenger.Departing Thu, 9 Jul.One-way flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Thu, 9 Jul, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 3,480, select.

Panama City.R 3,794 per passenger.Departing Thu, 6 Aug.One-way flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Thu, 6 Aug, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 3,794, select.

Panama City.R 4,200 per passenger.Departing Wed, 4 Nov.One-way flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Wed, 4 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 4,200, select.

Panama City.R 4,200 per passenger.Departing Mon, 26 Oct.One-way flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Mon, 26 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 4,200, select.

Panama City.R 4,200 per passenger.Departing Sun, 13 Sep.One-way flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sun, 13 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 4,200, select.

Panama City.R 4,205 per passenger.Departing Sat, 6 Feb.One-way flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sat, 6 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 4,205, select.

Panama City.R 4,246 per passenger.Departing Fri, 8 Jan.One-way flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 8 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 4,246, select.

Panama City.R 4,258 per passenger.Departing Fri, 4 Dec.One-way flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 4 Dec, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 4,258, select.

Panama City.R 4,258 per passenger.Departing Sat, 13 Mar.One-way flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sat, 13 Mar, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 4,258, select.

Panama City.R 6,170 per passenger.Departing Mon, 29 Jun.One-way flight with Arajet.Outbound indirect flight with Arajet, departs from Santo Domingo Las Americas on Mon, 29 Jun, arriving in Balboa.Price includes taxes and charges.From R 6,170, select.

Panama City.R 6,722 per passenger.Departing Sat, 11 Jul.One-way flight with Copa.Outbound direct flight with Copa departs from Santo Domingo Las Americas on Sat, 11 Jul, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 6,722, select.

Panama City.R 9,501 per passenger.Departing Mon, 29 Jun.One-way flight with Copa.Outbound direct flight with Copa departs from Santo Domingo Las Americas on Mon, 29 Jun, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 9,501, select.

Panama City.R 9,532 per passenger.Departing Tue, 1 Sep.One-way flight with Copa.Outbound direct flight with Copa departs from Santo Domingo Las Americas on Tue, 1 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 9,532, select.

Panama City.R 9,593 per passenger.Departing Wed, 4 Nov.One-way flight with Copa.Outbound direct flight with Copa departs from Santo Domingo Las Americas on Wed, 4 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 9,593, select.

Panama City.R 9,593 per passenger.Departing Mon, 26 Oct.One-way flight with Copa.Outbound direct flight with Copa departs from Santo Domingo Las Americas on Mon, 26 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 9,593, select.

Panama City.R 9,670 per passenger.Departing Fri, 4 Dec.One-way flight with Copa.Outbound direct flight with Copa departs from Santo Domingo Las Americas on Fri, 4 Dec, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 9,670, select.

Find the cheapest month to fly from Santo Domingo to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Santo Domingo to Panama City flights are currently cheapest in July.

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Direct flights from Santo Domingo to Panama City

Alternative Santo Domingo to Panama City routes

Looking for the cheapest, fastest or easiest route from Santo Domingo to Panama City? You could fly into the following airports instead.

Santo Domingo to Panama City: Flight information

The things to know before you go.

Cheapest flight found	R 3,480
Cheapest month to fly	July
Average flight time	2 hrs, 36 mins
Most popular airline	Copa
Average flights per week	122

Finding cheap flights from Santo Domingo to Panama City: Frequently asked questions

How many airports are there in Panama City?

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.

How much are return flights from Santo Domingo to Panama City?

The best price we found for a return flight from Santo Domingo to Panama City is R 7,245. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Santo Domingo to Panama City?

2 hours and 36 minutes is the average flight time from Santo Domingo to Panama City.

Which airlines fly direct from Santo Domingo to Panama City?

Copa, KLM and Air France fly direct from Santo Domingo to Panama City.

How many flights are there a week from Santo Domingo to Panama City?

As of June 2026, there are 94 flights per week flying from Santo Domingo to Panama City.

When is the cheapest time to fly from Santo Domingo to Panama City?

The cheapest month to fly from Santo Domingo to Panama City is usually July.

Which is the cheapest airport to fly into in Panama City?

If you're flying from Santo Domingo, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from R 7,245.

Which upcoming date is cheapest to fly from Santo Domingo to Panama City on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Santo Domingo to Panama City on Sunday, 19 July 2026.

Can I get a direct flight from Santo Domingo to Panama City?

Yes – the average flight time is 2 hours and 36 minutes.

How can I get the best flight deal from Santo Domingo to Panama City?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Panama City?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Panama City?

In June, the average temperature is usually around 27°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.

Which is the cheapest airline to fly from Santo Domingo to Panama City with?

The cheapest airline that flies to Panama City is Avianca. And the cheapest airline that flies to Balboa Airport is Copa.

Flying from Santo Domingo to Panama City: what you need to know

Santo Domingo has two main airports that could be the jumping-off point for your adventure. Check out your options for booking a flight from Santo Domingo to Panama City flying out of Santo Domingo Las Americas Airport (SDQ) or La Isabela International Airport (JBQ).
When it comes to working out where to land in Panama City, Panama City Tocumen International Airport (PTY) and Balboa Airport (BLB) are the primary gateways.
Take a direct Santo Domingo to Panama City flight and you'll be in the air for an average of 2 hours 35 minutes.
Panama City's timezone is UTC-5, which makes Panama City one hour behind Santo Domingo.
With 34 weekly flights between the two airports, Santo Domingo Las Americas Airport (SDQ) to Panama City Tocumen International Airport (PTY) is the busiest route. Hop on the earliest flight from Santo Domingo to Panama City with Copa Airlines at 05:14. If you prefer to make the most of your day before leaving, the last flight from SDQ to PTY is with Copa Airlines at 18:38.
To ensure you make your Santo Domingo to Panama City flight, leave enough time to navigate the airport and find your gate. Turning up two hours ahead of international departures and an hour before domestic flights is the general rule.
During popular months such as July, it's a good idea to get to the airport even earlier. Plan to arrive two hours before a domestic departure and four hours ahead for international flights when you travel during a peak period in general.

How to find the cheapest flights from Santo Domingo to Panama City

Get cheap Santo Domingo to Panama City flights by booking seven months ahead. According to our research, that's the ideal time for landing a bargain.
The best month for landing cheap plane tickets from Santo Domingo to Panama City is December. Use the 'Whole month' tool to compare all available prices, then choose the dates with the lowest fares.
There's no need to check every day to find out if fares have dropped when you set up a Price Alert. We'll update you as soon as a better deal is available on cheap flights from Santo Domingo to Panama City.
Find an affordable Santo Domingo to Panama City flight with the help of our filters. Select your ideal times, number of stops and airlines, then sort the results by 'Cheapest' to see the best deals.

Flying from Santo Domingo

Santo Domingo Las Americas Airport (SDQ)

Set out from Santo Domingo Las Americas Airport (SDQ) on a nonstop flight from Santo Domingo to Panama City. From SDQ, you can fly directly into Panama City Tocumen International Airport (PTY).
Copa Airlines is a leading airline that offers direct Santo Domingo to Panama City plane tickets from SDQ.
We make it simple to book a Santo Domingo to Panama City flight with a stopover. To see your options departing from Santo Domingo Las Americas Airport, uncheck 'Direct flights only.' Next, choose a flight that has a stop long enough to tour the city of your choice. Major stopovers include:
- Bogota Airport (BOG)
- Medellin Jose Maria Cordova Airport (MDE)
- San Jose Juan Santamaria Airport (SJO)
Travelling from central Santo Domingo to SDQ takes around 1 hour 15 minutes by public transport. If you drive, ride-share or take a taxi, you'll cover the 24 kilometres in 35 minutes or so, depending on traffic conditions.
After a hassle-free start to your travels? Stay near Santo Domingo Las Americas Airport. Whether you're catching an early flight from Santo Domingo to Panama City or just don't want to be rushed, these hotels have you covered:
Of the flights that depart from Santo Domingo Las Americas Airport, 76% land on time at their destination.

Arriving in Panama City

Panama City Tocumen International Airport (PTY)

The distance from Panama City Tocumen International Airport (PTY) to central Panama City is approximately 18 kilometres. It takes about 35 minutes to get to the centre driving.
It typically takes 50 minutes to get there on public transport.
The last thing you want is a lengthy journey to your hotel if you're getting in late on a flight from Santo Domingo to Panama City. Reserve one of these accommodation options near PTY instead:
Pick up a Panama City Tocumen International Airport rental car and discover Panama City and beyond with your own wheels. Avis, Dollar and MEX are leading providers to choose from here.
Reserving your vehicle from Panama City Tocumen International Airport about three weeks ahead gives you the best shot at securing a great deal.

Panama City Paitilla Airport (PAC)

Central Panama City is approximately 5 kilometres from Panama City Paitilla Airport (PAC). Make your way off your flight from Santo Domingo to Panama City and then be on the lookout for any airport signs directing you to the city centre.
You'll find some comfortable places to lay your head close to PAC. Settle in and get cosy after your Santo Domingo to Panama City flight at one of these well-located options:
Thrifty, Avis and Alamo make picking up a Panama City Paitilla Airport rental car simple. These suppliers are located in or around the terminal and will have you ready to go in a flash.
Call dibs on the best options. Reserving your ride from PAC three weeks ahead of time often means more savings and a wider range of vehicles.

Balboa Airport (BLB)

Travel to the centre after your flight from Santo Domingo to Panama City has arrived. Central Panama City is around 5 kilometres from Balboa Airport (BLB) and takes roughly 10 minutes to get there in a car.
The journey will take you about 20 minutes when travelling on public transport.
Whether you want a zippy compact for a solo trip or an SUV to fit a group of friends, you'll find the ideal Balboa Airport rental car for you. Browse the range of wheels available from names such as Sixt, Dollar and Thrifty.
Plan ahead and reap the rewards. Book your vehicle from BLB one week before your flight from Santo Domingo to Panama City for the best rates.

Best time to go to Panama City

July is the most popular month for flights from Santo Domingo to Panama City. To escape the crowds, go to Panama City in March.
Before locking in your Santo Domingo to Panama City tickets, think about the type of weather you enjoy. March is the warmest month in Panama City, with temperatures ranging from 21ºC (70ºF) to 32ºC (90ºF).
Look for cheap flights from Santo Domingo to Panama City in January if you'd rather travel when it's cooler. Temperatures are at their lowest then, ranging between 22ºC (72ºF) and 31ºC (88ºF) on average.

More about Panama City

After booking your flight from Santo Domingo to Panama City, find a hotel that keeps you close to what you want to see. Make one of these accommodation options your base for exploring Panama City:
There are so many things to do and see in this city it can be tricky to work out where to begin. San Felipe, Metropolitan Cathedral Basilica of Santa Maria the Ancient and Independence Square are leading attractions which should be on every Panama City itinerary.