Cheap Flights from San Francisco International to Knoxville

Compare San Francisco International to Knoxville flight deals

Find the cheapest month or even day of the year to fly to Knoxville

Book the best Knoxville fare with no extra fees

Flight deals from San Francisco International to Knoxville

Looking for a cheap last-minute deal or the best return flight from San Francisco International to Knoxville? Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from San Francisco International to Knoxville

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like San Francisco International to Knoxville flights are currently cheapest in May.

San Francisco International to Knoxville: Alternative routes

Compare routes from San Francisco International to Knoxville below. You may find an airport to fly into that's cheaper, faster, or easier than Knoxville.

San Francisco to Knoxville: Flight information

The things to know before you go.
Cheapest flight foundR 2,563
Cheapest month to flyMay

Finding cheap flights from San Francisco International to Knoxville: Frequently asked questions

The best price we found for a return flight from San Francisco International to Knoxville is R 4,468. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from San Francisco International to Knoxville. But we found flights with one or more stops from R 4,468.
As of February 2026, there are no flights flying from San Francisco International to Knoxville.
The cheapest month to fly from San Francisco International to Knoxville is usually March.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from San Francisco International Airport to Knoxville Airport on Monday, 9 March 2026.
No airlines currently offer direct flights between San Francisco International Airport and Knoxville Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Knoxville but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Knoxville is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Frontier Airlines offers the cheapest flight tickets to Knoxville.

Travelling from San Francisco International Airport (SFO) to McGhee Tyson Airport (TYS): what you need to know

  • To ensure you catch your SFO to TYS flight, allow plenty of time for things like baggage drop and finding your gate. Turning up two hours before international departures and one hour before domestic flights is the general travel rule.

  • Travelling during a peak time like August? Public holidays and other popular periods can mean longer queues at security. Play things extra safe and get there up to four hours ahead of international flights and two hours before domestic departures.

  • Consider adding a stopover when booking your ticket from San Francisco International Airport to McGhee Tyson Airport. Simply uncheck 'Direct flights only' to break up your journey, or enjoy a detour to a new and interesting place. Here are some options between SFO and TYS:

    • Harry Reid Airport (formerly McCarran Airport)

    • Dallas/Fort Worth International Airport

    • Hartsfield-Jackson Atlanta International Airport

How to find the cheapest flights from San Francisco International Airport (SFO) to McGhee Tyson Airport (TYS)

  • The cheapest price we've seen for a one-way San Francisco International Airport to McGhee Tyson Airport flight is R 2,563. A return ticket is currently R 4,468. Depending on the availability when you book, these fares can change.

  • It's a good idea to book ahead of time if you want to get cheap tickets from SFO to TYS. That's because airlines adjust prices based on demand, which tends to increase closer to departure.

  • The 'Whole month' tool shows you the cheapest flights from San Francisco International Airport to McGhee Tyson Airport across the month. It's an easy way to find a bargain if your travel dates aren't set in stone.

  • Picking up cheap flights from SFO to TYS is a cinch with Price Alerts. All you need to do is create one of these automatic alerts and we'll let you know as soon as a new discounted fare appears.

  • Tailor your flights with filters. Pick your departure and arrival times, total journey duration and airlines. You can also sort results by 'Best,' 'Fastest' or 'Cheapest' flights from San Francisco International Airport to McGhee Tyson Airport.

Handy information about San Francisco International Airport (SFO)

  • When it comes to San Francisco International Airport's on-time performance, data shows 77.36% of flights arrive within the scheduled timeframe.

  • Central San Francisco to San Francisco International Airport is around 21 kilometres. Depending on traffic, it'll take you about 20 minutes to get there if you're catching a cab, ride-sharing or driving.

  • You can expect a trip time of roughly 45 minutes when using public transport.

  • Have an early flight from San Francisco International Airport to McGhee Tyson Airport? Avoid the last-minute rush to the airport (and sneak in some extra snooze time) by choosing one of these hotels near SFO:

Arriving at McGhee Tyson Airport (TYS)

  • Book a hotel near TYS if you're on a late San Francisco International Airport to McGhee Tyson Airport flight. Select one of these options and avoid the hassle of a long transfer:

  • Get your adventure underway by picking up a McGhee Tyson Airport rental car. Grab a set of wheels from Budget, Alamo or Avis and experience the lesser-explored corners of Knoxville and beyond.

  • Get the best deal by booking your vehicle from McGhee Tyson Airport about three weeks ahead of your departure.

Getting from McGhee Tyson Airport (TYS) to central Knoxville

  • TYS is located at 2055 Alcoa Highway.

  • McGhee Tyson Airport to central Knoxville has a drive time of about 20 minutes. It's approximately 23 kilometres away.

When to fly to McGhee Tyson Airport (TYS)

  • The quietest month for a flight from San Francisco International Airport to McGhee Tyson Airport is February, while July is the busiest. Pick the best time to go to Knoxville based on whether you prefer a laid-back vibe or a more bustling atmosphere.

  • Before locking in your flight from San Francisco International Airport to McGhee Tyson Airport, consider the type of weather you like. July is the warmest month in Knoxville, with the temperature ranging from 17ºC (63ºF) to 32ºC (90ºF).

  • Look for cheap tickets from SFO to TYS in January if you'd rather travel during cooler conditions. Temperatures are at their lowest then, ranging between -6ºC (21ºF) and 11ºC (52ºF) on average.

Explore more of United States

  • Knoxville has plenty to offer, but there are so many other parts of United States waiting to be discovered. About 451 kilometres north of Knoxville, a visit to Columbus will keep you on the move. Start with leading sights like Franklin Park Conservatory and Botanical Gardens, Ohio Statehouse and German Village.

  • Around 467 kilometres north-west of Knoxville, Indianapolis is another essential stop in United States. Experience this destination's highlights firsthand at The Children's Museum of Indianapolis, Indianapolis Museum of Art and Indianapolis Zoo.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.