Cheap Flights from Santa Ana John Wayne to Knoxville

Compare Santa Ana John Wayne to Knoxville flight deals

Find the cheapest month or even day of the year to fly to Knoxville

Book the best Knoxville fare with no extra fees

Find the cheapest month to fly from Santa Ana John Wayne to Knoxville

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Santa Ana John Wayne to Knoxville flights are currently cheapest in April.

Santa Ana John Wayne to Knoxville: Alternative routes

Compare routes from Santa Ana John Wayne to Knoxville below. You may find an airport to fly into that's cheaper, faster, or easier than Knoxville.

Santa Ana to Knoxville: Flight information

The things to know before you go.
Cheapest flight foundR 2,766
Cheapest month to flyApril

Finding cheap flights from Santa Ana John Wayne to Knoxville: Frequently asked questions

The best price we found for a return flight from Santa Ana John Wayne to Knoxville is R 4,997. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Santa Ana John Wayne to Knoxville. But we found flights with one or more stops from R 4,997.
As of March 2026, there are no flights flying from Santa Ana John Wayne to Knoxville.
The cheapest month to fly from Santa Ana John Wayne to Knoxville is usually April.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Santa Ana John Wayne Airport to Knoxville Airport on Wednesday, 1 April 2026.
No airlines currently offer direct flights between Santa Ana John Wayne Airport and Knoxville Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Knoxville but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Knoxville is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Spirit Airlines offers the cheapest flight tickets to Knoxville.

Travelling from John Wayne Airport (SNA) to McGhee Tyson Airport (TYS): what you need to know

  • Arriving two hours before an international flight and one hour ahead of a domestic departure are travel rules worth sticking to. Be at the airport with enough time to board your SNA to TYS flight.

  • Flying during a peak time such as July? School holidays and other popular seasons can lead to longer queues and delays at check-in and security. Be extra cautious and arrive up to four hours before international flights and two hours before domestic departures.

  • If you want to explore another city along the way, simply deselect 'Direct flights only' when searching for your ticket from John Wayne Airport to McGhee Tyson Airport. Here are the top stopovers between SNA and TYS:

    • Hartsfield-Jackson Atlanta International Airport

    • Harry Reid Airport (formerly McCarran Airport)

    • Dallas/Fort Worth International Airport

How to find the cheapest flights from John Wayne Airport (SNA) to McGhee Tyson Airport (TYS)

  • R 2,766 is the lowest price for a one-way John Wayne Airport to McGhee Tyson Airport flight. Return flights start at R 4,997. These fares may change depending on demand and availability.

  • It's usually best to book as early as possible if you want to get cheap tickets from SNA to TYS. That's because flight prices are based on demand, which tends to rise closer to departure.

  • The 'Whole month' tool shows you the cheapest flights from John Wayne Airport to McGhee Tyson Airport across the entire month. It's a good way to find a bargain if your travel dates aren't set in stone.

  • You won't have to check every day to see if fares have gone down when you set up a Price Alert. We'll notify you as soon as there's a better deal on cheap flights from SNA to TYS.

  • Pick your ideal arrival and departure times, number of stops and airlines with the filters. Or sort your results by 'Cheapest' to get the best deals on flights from John Wayne Airport to McGhee Tyson Airport.

Handy information about John Wayne Airport (SNA)

  • SNA is located at 18601 Airport Way.

  • 81.53% of flights leaving John Wayne Airport arrive at their destination on schedule. Given its strong on-time performance, you're unlikely to experience delays when jetting out of SNA.

  • John Wayne Airport is around 8 kilometres from central Santa Ana. If you're driving, catching a cab or ride-sharing from the centre, it'll take you 15 minutes or so to get there, depending on the traffic.

  • Planning to catch public transport? Expect a journey time of around 1 hour 5 minutes.

  • Need a handy hotel near SNA? If you're boarding an early flight from John Wayne Airport to McGhee Tyson Airport, these accommodation options will have you moments from your departure lounge:

Arriving at McGhee Tyson Airport (TYS)

  • If you're getting in on a late John Wayne Airport to McGhee Tyson Airport flight, few things beat the convenience of being near the terminal. Grab your bags from the carousel and then be tucked up in bed shortly after at one of these options near TYS:

  • Get your adventure underway by picking up a McGhee Tyson Airport rental car. Grab a set of wheels from Budget, Alamo or Avis to explore Knoxville and beyond.

  • For the lowest price, book your vehicle from McGhee Tyson Airport about three weeks in advance.

Getting from McGhee Tyson Airport (TYS) to central Knoxville

  • You'll find TYS at 2055 Alcoa Highway.

  • McGhee Tyson Airport to central Knoxville has a drive time of about 20 minutes. It's approximately 23 kilometres away.

When to fly to McGhee Tyson Airport (TYS)

  • The quietest month for a flight from John Wayne Airport to McGhee Tyson Airport is February, while July is the most popular. Choose the ideal time to visit Knoxville based on whether you prefer a more relaxed vibe or a faster pace.

  • Book your flight from John Wayne Airport to McGhee Tyson Airport for July if you'd like to explore Knoxville during its warmest month. You can expect temperatures of between 17ºC (63ºF) and 32ºC (90ºF).

  • If you'd rather travel in cooler conditions, search for a cheap ticket from SNA to TYS in January. Temperatures average between -6ºC (21ºF) and 11ºC (52ºF) then.

Explore more of United States

  • Columbus is just one of the many cities in United States waiting to be discovered once you've taken in the sights of Knoxville. Around 451 kilometres away to the north, check out popular attractions including Franklin Park Conservatory and Botanical Gardens, Ohio Statehouse and German Village.

  • If you're ready to explore another major stop in United States, head for Indianapolis, about 467 kilometres north-west of Knoxville. The Children's Museum of Indianapolis, Indianapolis Museum of Art and Indianapolis Zoo are among its highlights.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.