Cheap Flights from St Louis to Santo Domingo

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Flight deals from St Louis to Santo Domingo

Looking for a cheap last-minute deal or the best return flight from St Louis to Santo Domingo? Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from St Louis to Santo Domingo

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like St Louis to Santo Domingo flights are currently cheapest in February.

Alternative St Louis to Santo Domingo routes

Looking for the cheapest, fastest or easiest route from St Louis to Santo Domingo? You could fly into the following airports instead.

St Louis to Santo Domingo: Flight information

The things to know before you go.
Cheapest flight foundR 2,437
Cheapest month to flyFebruary

Finding cheap flights from St Louis to Santo Domingo: Frequently asked questions

There are 3 airports in Santo Domingo: La Isabela International, Santo Domingo Las Americas and Samana.
The best price we found for a return flight from St Louis to Santo Domingo is R 5,497. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from St Louis to Santo Domingo. But we found flights with one or more stops from R 5,497.
As of February 2026, there are no flights flying from St Louis to Santo Domingo.
The cheapest month to fly from St Louis to Santo Domingo is usually March.
If you're flying from St Louis Airport, the cheapest airport near Santo Domingo is Santo Domingo Las Americas – which is 23.4 km away from the centre of Santo Domingo. We've found flights into this airport from R 5,497.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from St Louis Airport to Santo Domingo on Wednesday, 4 March 2026.
No airlines currently offer direct flights between St Louis Airport and Santo Domingo. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santo Domingo but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Santo Domingo is around 40 days in advance, so don’t leave your flight to the last minute.
In February, the average temperature is usually around 25°C. August is typically the warmest month in Santo Domingo, when it usually averages around 31°C. You can expect the least rain in March. The coldest month is January, with temperatures averaging 21°C. The rainiest month is September.
Currently, Frontier Airlines offers the cheapest flight tickets to Santo Domingo.

Travelling from Lambert-St. Louis International Airport (STL) to Santo Domingo: what you need to know

  • Santo Domingo is one hour ahead of St Louis, where Lambert-St. Louis International Airport is located. Santo Domingo observes the UTC-4 timezone.

  • Allow plenty of time to make your STL to Santo Domingo flight. Generally, it's best to arrive at least two hours before international departures and an hour ahead for domestic flights.

  • If you're heading away during a bank holiday or another peak period, give yourself more time. A good rule is two hours ahead of domestic flights and up to four hours before international departures. Queues at check-in and security will be longer.

  • Think about adding a stopover to potentially save on your flight ticket from STL to Santo Domingo. Just uncheck 'Direct flights only' during your search. Break up your trip (and maybe save some cash) by stopping at one of these airports:

    • Hartsfield-Jackson Atlanta International Airport (ATL)

    • Miami International Airport (MIA)

    • Orlando International Airport (MCO)

  • Travelling from central St Louis to STL takes about 35 minutes on public transport. If you drive, ride-share or get a cab, you'll cover the 16 kilometres in 20 minutes or so, depending on traffic conditions.

  • Want a leisurely start to your travels? Stay near STL. Whether you have an early flight from Lambert-St. Louis International Airport to Santo Domingo or want to avoid feeling rushed, these hotels are just the thing:

  • When it comes to the on-time performance of Lambert-St. Louis International Airport, 78.04% of flights arrive within the scheduled time frame.

  • The address for STL is 10701 Lambert International Blvd..

How to find the cheapest flights from Lambert-St. Louis International Airport (STL) to Santo Domingo

  • R 2,437 is currently the lowest price for a one-way Lambert-St. Louis International Airport to Santo Domingo flight. A return flight ticket starts at R 5,497. These fares may change based on availability.

  • Don't leave things to the last moment. You're more likely to land cheap flights from STL to Santo Domingo if you book in advance. Airlines often have some amazing early bird deals.

  • Scoring cheap tickets from Lambert-St. Louis International Airport to Santo Domingo is more likely if you're flexible with your travel dates. Try using the 'Whole month' function to access the lowest fares across every month and bag a fantastic deal.

  • Snapping up a cheap flight from STL to Santo Domingo is a breeze with Price Alerts. Simply set up one of these automatic notifications and we'll get in touch as soon as a better deal is available.

  • Choose your preferred arrival and departure times, number of stops and airlines with our filters. Then, sort the results for your flight from Lambert-St. Louis International Airport to Santo Domingo by 'Best,' 'Cheapest' or 'Fastest.'

Airports in Santo Domingo

Las Americas International Airport (SDQ)

  • Las Americas International Airport (SDQ) to the centre of Santo Domingo takes around 30 minutes by car. The centre is roughly 32 kilometres away.

  • Think about booking a hotel close to SDQ if you're coming in on a late flight from Lambert-St. Louis International Airport to Santo Domingo. Pick one of these accommodation options and make your first night all about catching up on rest:

  • Go where the road takes you with a Las Americas International Airport rental car. Book your wheels from Final Rentals, FlexWays or INFINITY RENT and discover more of Santo Domingo and beyond.

  • Booking your vehicle from Las Americas International Airport around one week ahead of your flight from STL to Santo Domingo can help you get the best possible rate.

Dr. Joaquin Balaguer International Airport (JBQ)

  • After your flight from Lambert-St. Louis International Airport to Santo Domingo has hit the tarmac, you can reach the city centre in around 25 minutes by car. Central Santo Domingo is roughly 19 kilometres from Dr. Joaquin Balaguer International Airport (JBQ).

  • Unpack your bag and relax not long after your STL to Santo Domingo flight at Micro Hotel Condo Suites. This comfy accommodation option is an easy drive from JBQ.

  • Pick up a Dr. Joaquin Balaguer International Airport rental car and see and do more with your own wheels. FlexWays is just moments from arrivals, so you'll be on the road in a flash.

  • Lock in the vehicle you want, not just what's available, by booking your ride from JBQ ahead of your arrival. You'll also avoid paying more than you have to, especially when the airport is busy.

Best time to go to Santo Domingo

  • Before booking your flights from Lambert-St. Louis International Airport to Santo Domingo, consider which time of year works best for you. High season in Santo Domingo offers a bustling atmosphere and plenty to do, while the off-season means you'll get better deals on hotels and fewer crowds.

  • Before booking a Lambert-St. Louis International Airport to Santo Domingo flight ticket, think about the kind of weather forecast you're hoping for. September is the warmest month in Santo Domingo, with temperatures ranging from 23ºC (73ºF) to 33ºC (91ºF).

  • Search for cheap tickets from STL to Santo Domingo in February if you'd rather travel during cooler conditions. Temperatures are at their lowest then, ranging between 19ºC (66ºF) and 29ºC (84ºF) on average.

More about Santo Domingo

  • Start your Santo Domingo trip off on the right foot by choosing the ideal place to stay. Once you've booked your flight from Lambert-St. Louis International Airport to Santo Domingo, browse our range of hotels including:

  • There are so many things to do and see in this city it can be difficult to know where to begin. National Palace, Alcazar de Colon and Basilica Cathedral of Santa Maria la Menor are major attractions which should be on every Santo Domingo itinerary.

Explore more of Dominican Republic

  • La Romana is just one of the many cities in Dominican Republic waiting to be discovered once you've seen the sights of Santo Domingo. Around 105 kilometres away to the east, its best attractions include Dye Fore Golf Course of Casa de Campo, Minitas Beach and La Estrella Park.

  • Puerto Plata is another essential stop in Dominican Republic and is around 161 kilometres north-west of Santo Domingo. No trip is complete without a visit to Fortaleza San Felipe, Teleferico Puerto Plata Cable Car and Malecon Puerto Plata.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.