Cheap Flights from Medellin to Panama City

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Flight deals from Medellin to Panama City

Looking for a cheap last-minute deal or the best return flight from Medellin to Panama City? If you want to travel next month, return fares start from R 3,188. Find the lowest prices on one-way and return tickets right here.

Panama City.R 2,005 per passenger.Departing Fri, 29 May.One-way flight with Wingo.Outbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Fri, 29 May, arriving in Balboa.Price includes taxes and charges.From R 2,005, select.

Panama City.R 2,037 per passenger.Departing Thu, 1 Oct.One-way flight with Wingo.Outbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Thu, 1 Oct, arriving in Balboa.Price includes taxes and charges.From R 2,037, select.

Panama City.R 2,079 per passenger.Departing Tue, 7 Apr.One-way flight with Wingo.Outbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Tue, 7 Apr, arriving in Balboa.Price includes taxes and charges.From R 2,079, select.

Panama City.R 2,140 per passenger.Departing Tue, 26 Jan.One-way flight with Wingo.Outbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Tue, 26 Jan, arriving in Balboa.Price includes taxes and charges.From R 2,140, select.

Panama City.R 2,208 per passenger.Departing Sat, 13 Jun.One-way flight with Wingo.Outbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Sat, 13 Jun, arriving in Balboa.Price includes taxes and charges.From R 2,208, select.

Panama City.R 2,580 per passenger.Departing Fri, 13 Nov.One-way flight with Wingo.Outbound indirect flight with Wingo, departs from Medellin Jose Maria Cordova on Fri, 13 Nov, arriving in Balboa.Price includes taxes and charges.From R 2,580, select.

Panama City.R 2,719 per passenger.Departing Thu, 3 Dec.One-way flight with Wingo.Outbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Thu, 3 Dec, arriving in Balboa.Price includes taxes and charges.From R 2,719, select.

Panama City.R 2,828 per passenger.Departing Thu, 16 Jul.One-way flight with Clic Air.Outbound indirect flight with Clic Air, departs from Medellin Enrique Olaya Herrera on Thu, 16 Jul, arriving in Balboa.Price includes taxes and charges.From R 2,828, select.

Panama City.R 2,852 per passenger.Departing Tue, 11 Aug.One-way flight with Wingo.Outbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Tue, 11 Aug, arriving in Balboa.Price includes taxes and charges.From R 2,852, select.

Panama City.R 2,904 per passenger.Departing Mon, 21 Sep.One-way flight with JetSmart.Outbound indirect flight with JetSmart, departs from Medellin Jose Maria Cordova on Mon, 21 Sep, arriving in Balboa.Price includes taxes and charges.From R 2,904, select.

Panama City.R 2,905 per passenger.Departing Sat, 18 Jul.One-way flight with Wingo.Outbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Sat, 18 Jul, arriving in Balboa.Price includes taxes and charges.From R 2,905, select.

Panama City.R 2,990 per passenger.Departing Wed, 16 Sep.One-way flight with Wingo.Outbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Wed, 16 Sep, arriving in Balboa.Price includes taxes and charges.From R 2,990, select.

Panama City.R 3,180 per passenger.Departing Fri, 13 Nov.One-way flight with Wingo.Outbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Fri, 13 Nov, arriving in Balboa.Price includes taxes and charges.From R 3,180, select.

Panama City.R 3,266 per passenger.Departing Tue, 31 Mar.One-way flight with Wingo.Outbound indirect flight with Wingo, departs from Medellin Jose Maria Cordova on Tue, 31 Mar, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 3,266, select.

Panama City.R 3,438 per passenger.Departing Tue, 31 Mar.One-way flight with Wingo.Outbound direct flight with Wingo departs from Medellin Jose Maria Cordova on Tue, 31 Mar, arriving in Balboa.Price includes taxes and charges.From R 3,438, select.

Panama City.R 3,452 per passenger.Departing Mon, 15 Feb.One-way flight with Avianca.Outbound indirect flight with Avianca, departs from Medellin Jose Maria Cordova on Mon, 15 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From R 3,452, select.

Find the cheapest month to fly from Medellin to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Medellin to Panama City flights are currently cheapest in May.

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Direct flights from Medellin to Panama City

Alternative Medellin to Panama City routes

Looking for the cheapest, fastest or easiest route from Medellin to Panama City? You could fly into the following airports instead.

Medellin to Panama City: Flight information

The things to know before you go.

Cheapest flight found	R 2,005
Cheapest month to fly	May
Average flight time	1 hr, 24 mins
Most popular airline	Copa
Average flights per week	207

Finding cheap flights from Medellin to Panama City: Frequently asked questions

How many airports are there in Panama City?

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.

How much are return flights from Medellin to Panama City?

The best price we found for a return flight from Medellin to Panama City is R 3,063. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Medellin to Panama City?

1 hour and 23 minutes is the average flight time from Medellin to Panama City.

Which airlines fly direct from Medellin to Panama City?

Copa, KLM and United fly direct from Medellin to Panama City.

How many flights are there a week from Medellin to Panama City?

As of March 2026, there are 828 flights per week flying from Medellin to Panama City.

When is the cheapest time to fly from Medellin to Panama City?

The cheapest month to fly from Medellin to Panama City is usually October.

Which is the cheapest airport to fly into in Panama City?

If you're flying from Medellin, the cheapest airport near Panama City is Balboa – which is 4.9 km away from the centre of Panama City. We've found flights into this airport from R 3,063.

Which upcoming date is cheapest to fly from Medellin to Panama City on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Medellin to Panama City on Friday, 16 October 2026.

Can I get a direct flight from Medellin to Panama City?

Yes – the average flight time is 1 hour and 22 minutes.

How can I get the best flight deal from Medellin to Panama City?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Panama City?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Panama City?

In March, the average temperature is usually around 28°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.

Which is the cheapest airline to fly from Medellin to Panama City with?

The cheapest airline that flies to Panama City is Wingo .

Flying from Medellin to Panama City: what you need to know

Planning your trip begins with working out where you'll fly out of in Medellin. Jose Maria Cordova International Airport (MDE) is the city's main base, so check out your options for reserving a flight from Medellin to Panama City departing from here.
Tocumen International Airport (PTY) and Panama Pacifico Airport (BLB) are Panama City's major entry points.
The average duration of a direct Medellin to Panama City flight is 1 hour 25 minutes.
Medellin and Panama City follow the same timezone, UTC-5.
Jose Maria Cordova International Airport (MDE) to Tocumen International Airport (PTY) is the most traveled route that connects these two cities. There are 72 departures a week to choose from. If you have things to finalize before heading off, the last flight from Medellin to Panama City is with Copa Airlines at 18:21. Opt for the first MDE to PTY departure operated by Copa Airlines at 05:02 to maximise your time in Panama City.
To ensure you make your Medellin to Panama City flight, leave enough time to navigate the airport and find your gate. Turning up two hours before international departures and an hour before domestic flights is the standard rule.
You'll likely experience bigger queues in popular months like August. Arriving up to four hours ahead of international flights and two hours for domestic departures will help ensure a smooth travel experience.

How to find the cheapest flights from Medellin to Panama City

The lowest price we've seen for a one-way ticket from Medellin to Panama City is R 2,005. For a return flight on this route, the best price is R 3,063. Depending on the availability when you book, these fares may change.
Score cheap Medellin to Panama City flights by booking two months ahead. According to our research, that's the ideal time frame for finding a bargain.
Schedule your trip for May. That's the best month for landing great bargains on plane tickets from Medellin to Panama City. If you're flexible with your dates, use the 'Whole month' tool to find the cheapest price across each month.
Spend less time searching for cheap flights from Medellin to Panama City by creating a Price Alert. We'll send you an email or push notification on the app when a new discounted fare appears.
Choose your preferred arrival and departure times, number of stops and airlines with the filters. Or sort your Medellin to Panama City flight results by 'Best,' 'Fastest' or 'Cheapest.'

Flying from Medellin

Jose Maria Cordova International Airport (MDE)

Jet off from Jose Maria Cordova International Airport (MDE) and fly straight through to Tocumen International Airport (PTY) or Panama Pacifico Airport (BLB). If you're looking for a direct flight from Medellin to Panama City out of MDE, those are your final stops.
You'll have your choice of airlines that offer direct Medellin to Panama City plane tickets out of MDE. Get on board with any of these:
Consider adding a stopover to potentially save money on your Medellin to Panama City flight. Just deselect 'Direct flights only' when searching for departures from Jose Maria Cordova International Airport. Break up your trip (and maybe save some cash) by stopping at one of these airports:
- El Dorado International Airport (BOG)
- Alfonso B. Aragon Airport (CLO)
- Rafael Nunez International Airport (CTG)
MDE is about 18 kilometres from central Medellin. If you're ride-sharing, catching a cab or driving from the centre, it'll take you 35 minutes or so to get there, depending on traffic conditions.
Searching for a convenient hotel near Jose Maria Cordova International Airport? If you're boarding an early flight from Medellin to Panama City, these accommodation options will put you moments from your departure gate:
When it comes to Jose Maria Cordova International Airport's on-time performance, 69.76% of flights complete their journey on time.

Arriving in Panama City

Tocumen International Airport (PTY)

The distance from Tocumen International Airport (PTY) to central Panama City is approximately 16 kilometres. It'll take you about 20 minutes to reach the centre driving.
It usually takes 1 hour 5 minutes to get there when travelling by public transport.
The last thing you want is a long journey to your hotel if you're getting in late on a flight from Medellin to Panama City. Check in to one of these accommodation options near PTY instead:
Begin your adventure by picking up a Tocumen International Airport rental car. Grab a set of wheels from Avis, Dollar or MEX and experience the lesser-explored corners of Panama City and beyond.
Reserving your vehicle from Tocumen International Airport around three weeks ahead boosts your odds of scoring a great price.

Marcos A. Gelabert International Airport (PAC)

Once your flight from Medellin to Panama City has hit the tarmac, you can reach the city centre in around 5 minutes by car. Central Panama City is approximately 2 kilometres from Marcos A. Gelabert International Airport (PAC).
The trip will take approximately 25 minutes on public transport.
There are some great places to lay your head close to BLB. Settle in and get cosy after your Medellin to Panama City flight at one of these well-located options:
Thrifty, Avis and Alamo make picking up a Marcos A. Gelabert International Airport rental car simple. These companies are located around or in the terminal and will get you on your way in no time.
Get first dibs on the best options. Securing your ride from PAC three weeks in advance often means better deals and a greater range of vehicles.

Panama Pacifico Airport (BLB)

Panama Pacifico Airport (BLB) is roughly 11 kilometres from central Panama City. It'll take you about 20 minutes to get to the city centre in a car after your flight from Medellin to Panama City.
Take control of the next chapter of your journey by picking up a Panama Pacifico Airport rental car. Sixt, Dollar and Thrifty are dependable companies for booking.
Get a payoff by planning ahead. Book your vehicle from BLB one week before your flight from Medellin to Panama City for the best rates.

Best time to go to Panama City

It's time to plan your trip dates for your flight from Medellin to Panama City. June is the busiest month to visit Panama City. If you prefer a more relaxed vibe, go in February.
The warmest month in Panama City is March, with temperatures ranging between 21ºC (70ºF) and 32ºC (90ºF). Lock in your Medellin to Panama City ticket then if that's your definition of good weather.
Search for cheap flights from Medellin to Panama City in February if you'd rather travel when it's cooler. Temperatures are at their lowest then, ranging between 22ºC (72ºF) and 31ºC (88ºF) on average.

More about Panama City

Once you've booked your flight from Medellin to Panama City, take your pick from prime hotels that put you close to the action. Make one of these accommodation options your base for exploring Panama City:
All great holidays should include some sightseeing. Panama Canal Museum, Casco Viejo and Cinta Costera are essential stops on your Panama City itinerary.

Explore more of Panama

You've done Panama City, now it's time to explore other corners of Panama. Travel around 6 kilometres north to San Miguelito to tick off its leading sights. From Iglesia Cristo Luz del Mundo to IDMJI SAN MIGUELITO and Iglesia Bautista Independiente Emanuel, there's plenty to keep you busy.
If you're eager to discover another great destination in Panama, head for Juan Díaz, about 11 kilometres north-east of Panama City. Malecon Costa Del Este, El Patio Human Friendly and Parque Los Robles Sur are key highlights.