Cheap Flights from Knoxville to Panama City

Compare Knoxville to Panama City flight deals

Find the cheapest month or even day of the year to fly to Panama City

Book the best Panama City fare with no extra fees

Flight deals from Knoxville Airport to Panama City

Looking for a cheap last-minute deal or the best return flight from Knoxville Airport to Panama City? If you want to travel next month, return fares start from R 9,842. Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Knoxville to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Knoxville to Panama City flights are currently cheapest in April.

Alternative Knoxville to Panama City routes

Looking for the cheapest, fastest or easiest route from Knoxville to Panama City? You could fly into the following airports instead.

Knoxville to Panama City: Flight information

The things to know before you go.
Cheapest flight foundR 4,493
Cheapest month to flyApril

Finding cheap flights from Knoxville to Panama City: Frequently asked questions

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
The best price we found for a return flight from Knoxville to Panama City is R 9,221. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Knoxville to Panama City. But we found flights with one or more stops from R 9,221.
As of March 2026, there are no flights flying from Knoxville to Panama City.
The cheapest month to fly from Knoxville to Panama City is usually May.
If you're flying from Knoxville Airport, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from R 9,221.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Knoxville Airport to Panama City on Tuesday, 19 May 2026.
No airlines currently offer direct flights between Knoxville Airport and Panama City. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.
In March, the average temperature is usually around 28°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
Currently, Delta offers the cheapest flight tickets to Panama City.

Travelling from McGhee Tyson Airport (TYS) to Panama City: what you need to know

  • Panama City is one hour behind Knoxville, where McGhee Tyson Airport is located. Panama City follows the UTC-5 timezone.

  • To avoid missing your TYS to Panama City flight, leave enough time to check in and drop off your luggage. Arriving two hours before international departures and one hour before domestic flights is the standard rule.

  • Longer lines at security and check-in are likely if you're heading away during high season, so give yourself even more breathing space. A good rule for peak periods? Arrive up to four hours ahead for international flights and two hours for domestic departures.

  • TYS is about 18 kilometres from central Knoxville. If you're driving, catching a cab or ride-sharing from the centre, it'll take you 20 minutes or so to get there, depending on traffic conditions.

  • Want a stress-free start to your travels? Stay near TYS. Whether you've booked an early flight from McGhee Tyson Airport to Panama City or just don't want to be rushed, these hotels are worth a look:

  • Of all flights departing from McGhee Tyson Airport, 78.98% land on schedule at their destination.

  • TYS's address is 2055 Alcoa Highway.

How to find the cheapest flights from McGhee Tyson Airport (TYS) to Panama City

  • R 4,493 is currently the lowest price for a one-way McGhee Tyson Airport to Panama City flight. Return flight tickets start at R 9,221. These fares can change based on demand.

  • Don't wait until the last minute. You're more likely to find cheap flights from TYS to Panama City if you book ahead. Airlines often have some fantastic early bird rates.

  • The 'Whole month' tool will show you the cheapest tickets from McGhee Tyson Airport to Panama City across the month. It's an easy way to snap up a bargain if your dates aren't set in stone.

  • Stay on top of deals for cheap flights from TYS to Panama City by creating a Price Alert. We'll send you an email or push notification on the app when a new low fare is offered.

  • Pick your ideal departure and arrival times, airlines and number of stops with our filters. Then, sort the results for your flight from McGhee Tyson Airport to Panama City by 'Best,' 'Fastest' or 'Cheapest.'

Airports in Panama City

Tocumen International Airport (PTY)

  • The distance from Tocumen International Airport (PTY) to central Panama City is roughly 21 kilometres. It takes about 20 minutes to get to the centre driving.

  • When travelling on public transport, expect a journey time of around 1 hour 5 minutes.

  • If you have a late flight from McGhee Tyson Airport to Panama City, few things beat the convenience of staying close to the terminal. Grab your bags from the carousel and then be showered and snoozing soon after at one of these hotels near PTY:

  • Get on the fast track to adventure by picking up a Tocumen International Airport rental car. Grab your wheels from Avis, Dollar or MEX to explore Panama City and beyond.

  • To get the lowest price, reserve your ride from Tocumen International Airport about three weeks in advance of your flight from TYS to Panama City.

Marcos A. Gelabert International Airport (PAC)

  • Central Panama City is located around 2 kilometres from Marcos A. Gelabert International Airport (PAC). After your flight from McGhee Tyson Airport to Panama City has landed and you've made your way out of the airport, expect a drive of about 5 minutes.

  • The trip will take about 25 minutes on public transport.

  • Hang the 'Do not disturb' sign on your door and rest at a hotel close to PAC. Here are a few options where you can check in after your TYS to Panama City flight:

  • The quickest way to reach your destination is with a Marcos A. Gelabert International Airport rental car. Collect a set of wheels from Thrifty, Avis or Alamo and be off and running.

  • Avoid paying extra. Reserving your ride three weeks before your arrival at PAC can get you a lower rate.

Panama Pacifico Airport (BLB)

  • Set your sights on the city centre after your flight from McGhee Tyson Airport to Panama City has arrived. Central Panama City is about 16 kilometres from Panama Pacifico Airport (BLB) and takes roughly 20 minutes to reach by car.

  • If you don't want to make your way into the centre, find a hotel close to BLB. Get comfortable at one of these options after your TYS to Panama City flight:

  • Start your trip without worrying about how to get to where you're going with a Panama Pacifico Airport rental car. You can book your wheels with trusted companies here like Sixt, Dollar and Thrifty.

  • If you're after a specific make or model, book your ride from BLB about one week ahead of your flight from McGhee Tyson Airport to Panama City. This gives you a better chance of getting the car you want, along with a better price.

Best time to go to Panama City

  • Carefully consider your travel dates before booking your flight from McGhee Tyson Airport to Panama City. The city comes alive in peak season, but hotel rates are usually higher and top attractions can be busy. Visit Panama City in the low season for a quieter vibe.

  • Lock in a McGhee Tyson Airport to Panama City flight ticket with a departure in March if you want to experience the city during its warmest month. Expect temperatures to range from 21ºC (70ºF) to 32ºC (90ºF).

  • If you like cooler conditions, look for a cheap ticket from TYS to Panama City in February when temperatures average between 22ºC (72ºF) and 31ºC (88ºF).

More about Panama City

  • When it comes to searching for somewhere to lay your head, you'll find the top stays in Panama City right here. Check out these options once you've locked in your flight from McGhee Tyson Airport to Panama City:

  • There are so many things to do and see in this city it can be tricky to know where to begin. Casco Viejo, Panama Canal Museum and Cinta Costera are top attractions which should feature on any well-planned Panama City itinerary.

Explore more of Panama

  • Panama City has plenty going for it, but there are so many other parts of Panama you should also see. Around 322 kilometres west of Panama City, a trip to David will keep your itinerary busy. Don't miss top attractions like Parque Cervantes, Altos del Rio Park and Coquito Hills Park.

  • If you're ready to explore another great destination in Panama, consider Santiago de Veraguas, roughly 193 kilometres south-west of Panama City. Santiago the Apostle Cathedral, Santiago de Veraguas, The Church of Jesus Christ of Latter Day Saints and La Placita San Juan De Dios are among its highlights.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.