Cheap Flights from Knoxville to San Diego

Compare Knoxville to San Diego flight deals

Find the cheapest month or even day of the year to fly to San Diego

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Flight deals from Knoxville to San Diego

Looking for a cheap last-minute deal or the best return flight from Knoxville Airport to San Diego? If you want to travel next month, return fares start from R 3,787. Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Knoxville to San Diego

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Knoxville to San Diego flights are currently cheapest in June.

Alternative Knoxville to San Diego routes

Looking for the cheapest, fastest or easiest route from Knoxville to San Diego? You could fly into the following airports instead.

Knoxville to San Diego: Flight information

The things to know before you go.
Cheapest flight foundR 1,707
Cheapest month to flyJune

Finding cheap flights from Knoxville to San Diego: Frequently asked questions

There are 2 airports in San Diego: San Diego International and McClellan-Palomar.
The best price we found for a return flight from Knoxville to San Diego is R 3,576. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Knoxville to San Diego. But we found flights with one or more stops from R 3,576.
As of May 2026, there are no flights flying from Knoxville to San Diego.
The cheapest month to fly from Knoxville to San Diego is usually August.
If you're flying from Knoxville Airport, the cheapest airport near San Diego is San Diego International – which is 4.1 km away from the centre of San Diego. We've found flights into this airport from R 3,576.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Knoxville Airport to San Diego on Sunday, 16 August 2026.
No airlines currently offer direct flights between Knoxville Airport and San Diego. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to San Diego but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to San Diego is around 40 days in advance, so don’t leave your flight to the last minute.
In May, the average temperature is usually around 17°C. August is typically the warmest month in San Diego, when it usually averages around 28°C. You can expect the least rain in June. The coldest month is December, with temperatures averaging 10°C. The rainiest month is February.
Currently, Allegiant Air offers the cheapest flight tickets to San Diego.

Travelling from McGhee Tyson Airport (TYS) to San Diego: what you need to know

  • San Diego is three hours behind Knoxville, where McGhee Tyson Airport is located. San Diego runs on the UTC-7 timezone.

  • Leave plenty of time to make your TYS to San Diego flight. A good rule of thumb is to arrive at least two hours before international departures and an hour ahead for domestic flights.

  • If you're heading away during a bank holiday or another peak period, allow for even more time. A good rule is two hours before domestic flights and up to four hours before international departures. Check-in and security lines will be longer.

  • To get to TYS from central Knoxville, it'll take about 20 minutes if you're travelling by car. It's roughly 18 kilometres from the airport to the city centre.

  • Looking for a hotel close to TYS? If you've booked an early flight from McGhee Tyson Airport to San Diego, these stays will get you from your pillow to the plane in no time:

  • When it comes to McGhee Tyson Airport's on-time performance, 78.98% of flights arrive within the expected time frame.

  • You'll find TYS at 2055 Alcoa Highway.

How to find the cheapest flights from McGhee Tyson Airport (TYS) to San Diego

  • The best price we've seen for a one-way McGhee Tyson Airport to San Diego flight is R 1,707. The cheapest price for a return flight is R 3,576. Keep in mind fares may change due to availability at the time of booking.

  • To pick up cheap flights from TYS to San Diego, book in advance. Airlines typically offer lower prices when flights are first released.

  • The 'Whole month' search tool will show you the cheapest tickets from McGhee Tyson Airport to San Diego across the month. It's a great way to find a bargain if your travel dates aren't set in stone.

  • Picking up a cheap flight from TYS to San Diego is easy with Price Alerts. Simply create one of these automatic notifications and we'll let you know as soon as there's a better deal.

  • Find an affordable flight from McGhee Tyson Airport to San Diego with the help of our filters. Choose your ideal times, number of stops and airlines, then sort the results by 'Cheapest' to see the best deals.

Airports in San Diego

San Diego International Airport (SAN)

  • San Diego International Airport (SAN) is around 5 kilometres from central San Diego. If you're grabbing a cab or a ride-share, the drive takes roughly 10 minutes.

  • When travelling by public transport, expect a journey time of around 20 minutes.

  • If you have a late flight from McGhee Tyson Airport to San Diego, few things beat the convenience of staying close to the terminal. Collect your bags from the carousel and then be showered and resting not long after at one of these accommodation options near SAN:

  • Pick up a San Diego International Airport rental car and explore San Diego and beyond with your own set of wheels. Thrifty, Dollar and Budget are top outlets you can book with here.

  • Reserving your ride from San Diego International Airport about two weeks in advance of your flight from TYS to San Diego can help you secure the lowest rate.

  • SAN is located at N Harbour Dr.

McClellan-Palomar Airport (CLD)

  • After your flight from McGhee Tyson Airport to San Diego has hit the tarmac, you can get to the city centre in around 40 minutes by car. Central San Diego is roughly 56 kilometres from McClellan-Palomar Airport (CLD).

  • You can expect the trip to take roughly 2 hours 15 minutes on public transport.

  • Place the 'Do not disturb' sign on your door and relax at a hotel close to CLD. Here are a few options where you can settle in after your TYS to San Diego flight:

  • Forget about inconvenient public transport timetables or cab lines. Pick up a McClellan-Palomar Airport rental car and let the journey unfold your way. Check out the availability and rates from Budget, Hertz and Avis.

  • Get your ideal vehicle, not just what's available, by securing your ride from CLD ahead of time. You'll also avoid paying extra, especially when demand is high.

Best time to go to San Diego

  • Before you book your flights from McGhee Tyson Airport to San Diego, consider which time of year works best for you. Peak season in San Diego offers a bustling atmosphere and plenty of activities, while the off-season brings better hotel deals and fewer crowds.

  • The warmest month in San Diego is August, with temperatures ranging between 17ºC (63ºF) and 28ºC (82ºF). Book your McGhee Tyson Airport to San Diego flight ticket then if that's your definition of good weather.

  • February sees average temperatures of between 7ºC (45ºF) and 23ºC (73ºF). Look for a cheap ticket from TYS to San Diego around that time if you like cooler conditions.

More about San Diego

  • Start your San Diego trip off on the right foot by choosing the perfect place to stay. As soon as you've booked your flight from McGhee Tyson Airport to San Diego, explore our selection of hotels including:

  • USS Midway Museum and San Diego Zoo are just two of the leading attractions to add to your San Diego travel itinerary. Continue your sightseeing adventures at SeaWorld San Diego.

Explore more of United States

  • Los Angeles is just one of the many places in United States waiting to be explored once you've taken in the sights of San Diego. Around 177 kilometres away to the north-west, top sights here include Griffith Observatory, The Broad and La Brea Tar Pits & Museum.

  • If you're eager to discover another corner of United States, consider Phoenix, about 483 kilometres east of San Diego. Desert Botanical Garden, Heard Museum and Papago Park are among its highlights.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.